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pandora earrings AbstractStudy question Do men starting treatment with prostate specific antagonists have increased risk of fall and fracture?Methods Administrative datasets from the province of Ontario, Canada, that contain patient level data were used to generate a cohort of 147084 men aged 66 years who filled their first outpatient prescription for prostate specific antagonists tamsulosin, alfuzosin https://www.jewelryuh85.top, or silodosin between June 2003 and December 2013 (exposed men) plus an equal sized cohort matched 1:1 (using a propensity score model) who did not initiate antagonist therapy. The primary outcome was a hospital emergency room visit or inpatient admission for a fall or fracture in the 90 days after exposure.Study answer and limitations The men exposed to prostate specific antagonist had significantly increased risks of falling (odds ratio 1.14 (95% CI 1.07 to 1.21), absolute risk increase 0.17% (0.08 to 0.25%)) and of sustaining a fracture (odds ratio 1.16 (1.04 to 1.29), absolute risk increase 0.06% (0.02 to 0.11%)) compared with the unexposed cohort. This increased risk was not observed in the period before antagonist use. pandora earrings
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